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Comparing the schistosomicidal activity against juvenile worms with that of PZQ reported in previous in vivo studies 61 , the inhibitors reported herein show superior schistosomicidal activity to PZQ at the worm developmental stage in mice

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198,199 Therefore, the NAD + -dependent enzymatic activity of PARP-1 is a crucial regulator of gene expression via protecting the genome from aberrant hypermethylation

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